NGVB

The National Gene Vector Biorepository and Coordinating Center (NGVB), funded by the National Heart, Lung and Blood Institute (NHLBI), National Institutes of Health (NIH), is charged with enhancing the research and clinical environment for gene therapy investigators. In support of this mission, the goals of the NGVB are to provide the following: (1) maintain a database of pre-clinical pharmacology and toxicology studies (Pharm/Tox database) to support Investigational New Drug (IND) submissions to the Food and Drug Administration (FDA); (2) provide a reagent repository to support pre-clinical and clinical gene therapy studies; (3) provide biorepository and archiving services; (4) provide educational material about gene therapy; (5) provide IND-enabling testing services; and (6) conduct research related to gene therapy safety. More information about NGVB is available here.

The National Gene Vector Biorepository web application plays a key role in enabling the goals of the project. Originally developed by Dr. Jim Mullen of the IU Advanced Biomedical IT Core (ABITC) group, the project has been maintained by Ryan Long formerly also of the ABITC group. Ryan is currently a member of the SCA team and brought this project with him when he moved into our group.

As of March 2022, we are in the process of adding data management, data retrieval/download capabilities to the web application. We are also refactoring the codebase to use current web technologies that we use in other SCA projects.